회원학회
회원학회
| 번호 | 연구제목 | 연구자 | 연구기간 | 발표실적 |
|---|---|---|---|---|
| 내용 | ||||
| 3 | Ovalbumin Induces Atopic Dermatitis-like Skin Lesions in Different Species of mice : pilot study | 길태영, 진보람, 안효진 | 2021 ~ | 학회지 |
| Objectives: Atopic dermatitis (AD) is an easily recurrent inflammatory skin disease. Since AD has complex pathology, people have been investigating it on different aspects with various experimental models. One of them is in vivo model which has spontaneously developed AD-like skin lesions by various inducers. Methods: In this study, two kinds of mouse species were applied in the experiment; BALB/c and C57BL/6 mice. We compared features among the animal species making AD mouse model with protein allergen, ovalbumin. AD-like skin lesions were induced by ovalbumin on two kinds of scheme and were evaluated with the histological results and size of spleen which is a critical immunological organ. Also, we measured the level of immunoglobulin E in serum. In addition, we investigated the results of ovalbumin induced-AD-like skin lesions along with obesity. Results and Conclusion: We evaluated weight of organs and thickness of epidermis. These results suggest the possibility of the appropriate in vivo experimental model for AD or the comorbidity with obesity. Keywords : Moebius syndrome; facial palsy; eye abduction; MRI; treatment; acupunctur |
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| 2 | 측만증에 대한 도인 운동요법의 효과– 체계적 문헌 고찰 - | 김은정, 성원석, 박서현 | 2021 ~ | 학회지 |
| Objectives: Atopic dermatitis (AD) is an easily recurrent inflammatory skin disease. Since AD has complex pathology, people have been investigating it on different aspects with various experimental models. One of them is in vivo model which has spontaneously developed AD-like skin lesions by various inducers. Methods: In this study, two kinds of mouse species were applied in the experiment; BALB/c and C57BL/6 mice. We compared features among the animal species making AD mouse model with protein allergen, ovalbumin. AD-like skin lesions were induced by ovalbumin on two kinds of scheme and were evaluated with the histological results and size of spleen which is a critical immunological organ. Also, we measured the level of immunoglobulin E in serum. In addition, we investigated the results of ovalbumin induced-AD-like skin lesions along with obesity. Results and Conclusion: We evaluated weight of organs and thickness of epidermis. These results suggest the possibility of the appropriate in vivo experimental model for AD or the comorbidity with obesity. Keywords : Moebius syndrome; facial palsy; eye abduction; MRI; treatment; acupunctur |
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| 1 | 천연물 외용제를 적용한 아토피피부염 증례 및 임상 연구 고찰 | 서광일, 김규석 | 2021 ~ | |
| Objectives: To investigate the characteristics of topical agents including natural products using for atopic dermatitis treatment via a review on the cases and clinical trials. Methods: Through a search on Pubmed, EMBASE, Cochrane library, DBPIA, NDSL, and OASIS, we selected papers that applied natural products externally for atopic dermatitis and analyzed them. Results: Finally, Seventeen papers were selected. As the primary outcome, changes in the SCORAD and EASI, were the most used. The most frequent type of external formulation was cream. In terms of the frequency of use, it was used at least twice a day in all studies. When evaluated based on SCORAD, EASI, SH and TEWL, the improvement effect on atopic dermatitis was highest when the ointment formulation and the moisturizer formulation were used. A few side effects of topical agents including natural products were observed, but most were mild symptoms and no serious side effects occurred. Conclusion: This study is meaningful in that it has drawn a significant trend for studies that have been published in the last 5 years that contain a single intervention for topical agents including natural products, and that it presents the direction and evidence for the application of external therapy to increase the therapeutic effect of atopic dermatitis. Keywords : Atopic dermatitis, Natural extract, Topical treatment |
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