| With infectious diseases and an aging population on the rise worldwide, there is a growing interest in boosting immunity to combat them. We aim to identify forest resources that can enhance immune function and scientifically prove their efficacy. We examined three different types of gami-saengmaeksan can increase the immune function in cyclophosphamide-induced immunosuppression mice. First, we injected cyclophosphamide (50 mg/kg) twice to induce immunosuppression. Then, three different types of gami-saengmaeksan (Prunus davidiana Carrière gami-saengmaeksan; PDS, Chaenomeles sinensis Koehne gami-saengmaeksan; CSS, Pyrus pyrifolia Nakai gami-saengmaeksan; PPS) 200 mg/kg/day were oral administered for 14 days. In order to confirm the immune-enhancing effect three different types of gami-saengmaeksan, we analyzed body weight chagne, the number of immune cells in blood, cytokines, and immunoglobulins levels in serum. Cyclophosphamide was decreased the mice body weight and the number of immune cells in blood. However, PDS and PPS have significantly increased the body weight, white blood cell, neutrophil, lymphocyte and monocyte count. Also, they were increased immune-related cytokines (IFN-γ, IL-2, IL-4, IL-6, IL-10, and TNF-α) and immunoglobulins (IgA, IgG, and IgM) levels in serum. But, CSS were slightly increased body weight, immune cells, cytokines, and immunoglobulins levels, non-significance was observed. The results suggest that the three types of gami-saengmaeksan can be used as ingredients in dietary supplements to immune enhancing. |
| Non-small cell lung cancer(NSCLC) is a highly malignant tumor with limited treatment options. Conventional chemotherapy significant has limitations, including drug resistance and side effects. In this study, we investigated the anticancer effects of Codonopsis lanceolata root extract(CLRE), a traditional medicinal herb, on the human lung cancer cell line A549. Our results showed that CLRE inhibited A549 cell proliferation, migration, and invasion. Furthermore, CLRE effectively suppressed epithelial-to-mesenchymal transition(EMT) markers, including N-cadherin, vimentin, and MMP-9, induced by TGF-β1. Also CLRE inhibited cell migration and invasion in A549 cells through the downregulation of the PI3K/AKT signaling pathway. These findings suggest that CLRE has potential as a natural anticancer agent or adjunct therapy for NSCLC by inhibiting cell proliferation and EMT processes. Further studies are needed to elucidate the underlying mechanisms and assess the safety and therapeutic potential of CLRE in preclinical and clinical studies. |
| As a previous study to determine the factors influencing the level and variability of Chiljeong, the influence of Sasang Constitution and MBTI preferences on mood level and variability was examined. Among the 87 students of Korean Medicine attending D University who completed the Sasang Constitutional test and MBTI personality test, a Mood Survey was conducted and 83 of them were selected. Data were analyzed using the chi-squared test, ANOVA, independent sample t-test, and nonparametric test in IBM SPSS 22.0 for Windows. The mood level in Sasang Constitutions was highest in Soyang-in and Soeum-in, while Taeeum-in, Taeyang-in, and unclassified showed no differences. There was no difference in mood variability among Sasang Constitutions. The mood level was influenced by the direction of energy of MBTI preferences. There was no difference in mood variability between MBTI preferences. The mood level was influenced by Sasang Constitution and the direction of energy of MBTI preferences, but mood variability was not influenced by them. |
| In this paper, we attempted to link the theories of korean medicine and medicine on ‘Heart controls the blood vessels (心主血脈)’, ‘Spleen controls the blood (脾統血)’ and ‘Liver possesses the blood (肝藏血)’ related to blood circulation for the new possibility of theorizing integrative medicine. ‘Heart controls the blood vessels (心主血脈)’, which is explained as the function of blood that nourishes the five viscera and six bowels under the control of the heart, can be interpreted as the vascular system of the dynamics of blood movement through the cardiovascular system and the function of blood flow dispersing to tissues. ‘Spleen controls the blood (脾統血)’, which enables the normal production and movement of blood, can be interpreted as the function of vascular endothelial cells such as the role of permeability barrier between plasma and interstitial fluid, regulation of the amount of other substances, mediation of angiogenesis, production of damage response factors, and secretion of substances that regulate coagulation and anticoagulation. The ‘Liver possesses the blood (肝藏血)’, which regulates blood flow according to metabolic volume, can be interpreted as the function of arterioles that distribute the flow to various organs and tissues and efficiently transfer blood flow to the metabolic needs of individual tissues. The process of theorizing integrated medicine is necessary because it can provide opportunities for the use of multidisciplinary approaches and cooperation, and because it can develop a curriculum that can balance the universality of health care education based on biomedical science and the professionalism of korean medicine doctors. |
