| We conducted an online survey to understand the current status of Korean Medicine clinical practice related to Gastric Cancer(GC) to develop the GC Korean Medicine Clinical Practice Guidelines (CPG). Using the self-written survey method of the online survey platform, subjects who wanted to participate in the survey for adults aged 19 or older used to answer each questionnaire online from September 20 to October 22, 2021. All raw data were systematically cleaned and analyzed. A total of 134 respondents participated in the online survey, and all respondents had experience in gastric cancer treatment. We also obtained data related to the specific methods of diagnosis, treatment, and prognosis management for gastric cancer patients used at various sites of care. This online survey will help us develop a GC CPG that will contribute to the standardization of Korean Medicine guidelines and improve their reliability. Our findings will provide valuable data and resources for future clinical studies on GC. |
| This study examined the effectiveness of Korean medicine (KM) treatment with Mutong(No-pain) pharmacopuncture (MP) as the main treatment for a patient with plantar fasciitis. A 58-year-old man diagnosed with plantar fasciitis visited OOO KM clinic with pain in his right heel that persisted even after 2 months of physical therapy from more than 6 months after the onset, and underwent 4 treatments focusing on MP. Treatment effect was measured by NRS, FFI, PDI, and EQ-VAS. All scores improved after treatment. In particular, about 70% of symptoms improved at the first treatment, and improved to an asymptomatic state at the end of treatment. No recurrence of symptoms was confirmed until about 4 months after the end of treatment. This study suggests that KM treatment focusing on MP may reduce pain and improve function in a short period of time in patients with plantar fasciitis. More evidence will be needed. |
| Gastroesophageal reflux disease(GERD) is a disease that occurs when stomach acid repeatedly flows back into the tube connecting the mouth and esophagus. Traditional Korean Medicine(TKM) has been widely used since the ancient times to treat GERD. However, as the treatment method has not been standardized and inconsistent in clinical practice, it may be necessary to review the classical and modern literatures to understand how the TKM treatment of GERD has been changed. Seven databases were searched and selected 54 published books. The classical books from The Yellow Emperor's Classic of Internal Medicine to the end of the Joseon Dynasty, and the modern books published as first editions from 1989 to 2022 were reviewed. This study compared the differences and similarities of understanding GERD in the classical and modern literatures according to the main symptom and aetiology, and the acupuncture and moxibustion treatment points used with frequencies. In classical literature, the view of GERD was symptom-oriented such as fever, nausea, vomiting, phlegm-fire, gastric upset, acid regugitation, whereas the modern literature mainly classified the disease as organ-oriented combined with the condition of illness, particularly including in-coordination of the liver and stomach Qi. The most frequently used treatment points cross the literatures were CV 12, and modern literature included SP 4 and PC 6. Both of the classic and modern literature viewed that GERD is due to inappropiate eating habit or food, and modern literature additionally concerned more complex causes likely stress, which had leaded to various treatment points. Further study on the treatment points by diagnosis identification is may be necessary. |
| The purpose of this study is to examine the antioxidant effect of hamyang wild-simulated ginseng and ginseng berry complex(HGC) and to investigate the mechanism of anti-inflammatory effect on macrophage cell line (RAW264.7 cells). For antioxidant activity of HGC was measured by total polyphenol contents were estimated with folin-ciocalteu method, and total flavonoid contents were estimated with aluminum chloride methods. And, assessed with 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azino-bis-3-ethylbenzothiazoline-6-sulphonic acid (ABTS) radical scavenging activity assay. MTT assay was performed to determine the effect of HGC on cell viability in RAW264.7 cells. In addition, anti-inflammatory effect of HGC was investigated in RAW264.7 cells. RAW 264.7 cells, in which an inflammatory response was induced by lipopolysarccharide (LPS), were treated with HGC, and nitric oxide production was measured by griess assay. And protein expression level of inflammatory cytokine and phosphorylation of MAPK signaling pathways were confirmed by western blot analysis. Total polyphenols and flavonoids contents in HGC were quantified, and increased DPPH and ABTS radical scavenging activity in a concentration-dependent manner was confirmed. In addition, HGC was significantly inhibited nitric oxide (NO) production and inflammatory cytokine (iNOS, IL-1β, IL-6, and TNF-α) expression in LPS-stimulated RAW264.7 cells. Also, HGC was significantly inhibited the phosphorylation of MAPK signaling pathways. These results suggest that HGC can be used as effective herbal medicine extract for antioxidant and anti-inflammatory effect. As a result, it is thought that HCG can be used as a functional material effective for antioxidant and anti-inflammatory effects. And it will be possible to promote industrialization using hamyang wild-simulated ginseng and ginseng berry, and to increase high-value-added. |
