회원학회

회원학회

번호 연구제목 연구자 연구기간 발표실적
내용
89 석류 폴리페놀의 피부 노화 억제 효과에 대한 보혈(補血)·보신(補腎) 관점의 동서의학적 융합 고찰 – NAD⁺–미토콘드리아 축을 중심으로 조현석 2025-07-01 ~ 학회지
Objects: Skin aging is a complex biological process reflecting systemic aging and energy metabolic decline, manifested through reduced regeneration capacity, chronic inflammation, and extracellular matrix degradation. In Korean medicine, skin aging is traditionally interpreted as a consequence of kidney essence (腎精) depletion, blood (血) and yin-blood (陰血) deficiency, and impaired circulation of qi and blood (氣血). Recent advances in aging research have highlighted the NAD⁺–mitochondrial axis as a central mechanism underlying cellular aging. This study aims to propose an integrative theoretical model that connects the anti-aging effects of pomegranate polyphenols with the NAD⁺–mitochondrial pathway and the Korean medicine concepts of blood and kidney tonification in the context of skin aging.
Methods: A narrative review was conducted focusing on recent studies addressing mitochondrial dysfunction, NAD⁺ decline, and skin aging, as well as pharmacological and biological research on pomegranate polyphenols and their metabolites, particularly urolithin A. In parallel, classical and contemporary Korean medicine literature on skin aging, blood deficiency, kidney deficiency, and tonic herbal formulas such as Liuwei Dihuang Decoction (六味地黃湯) was reviewed. Based on this synthesis, a theoretical framework integrating modern molecular aging mechanisms with Korean medicine pathology was constructed.
Conclusions: Pomegranate polyphenols exhibit skin anti-aging and slow-aging potential through mitochondrial quality control, mitophagy activation, and indirect maintenance of NAD⁺ homeostasis. These mechanisms correspond structurally to the Korean medicine concepts of preserving kidney essence and stabilizing blood and yin-blood. When combined with Liuwei Dihuang–based tonifying strategies and acupuncture interventions aimed at regulating qi–blood circulation, pomegranate may function as a key modulator that slows the rate of skin aging rather than merely enhancing short-term repair. This integrative model provides a theoretical foundation for connecting molecular aging biology with Korean medicine–based skin anti-aging strategies and supports future clinical and experimental research in integrative dermatological aging management.
88 식물성 멜라토닌 섭취가 수면 질 및 피부 노화 지표에 미치는 영향: 한의학 음혈(陰血) 허손(虛損) 병리 관점에서 조현석 2025-07-01 ~ 학회지
Objects: This study aims to examine the effects of plant-derived melatonin intake on sleep quality and skin aging indicators, and to interpret its physiological significance through an integrative framework combining modern sleep physiology with the Korean medicine concept of Yin-Blood (陰血) deficiency. By linking sleep disturbance, melatonin dysregulation, and skin aging, this review seeks to establish a theoretical basis for sleep-based anti-aging strategies from an East–West medical perspective.
Methods: A narrative literature review was conducted focusing on studies related to melatonin, sleep quality, circadian rhythm regulation, skin aging, and antioxidant mechanisms. Relevant research in sleep medicine, dermatology, and anti-aging biology was analyzed alongside classical and contemporary Korean medicine literature addressing insomnia (不眠), Yin-Blood deficiency, and skin nourishment. Particular attention was given to the physiological characteristics of plant-derived melatonin as a bioactive complex rather than a single compound.
Conclusions: Plant-derived melatonin appears to improve sleep quality through circadian rhythm stabilization while simultaneously exerting antioxidant and cytoprotective effects on skin tissue. These actions correspond structurally to the Korean medicine concept of nourishing Yin-Blood, calming the spirit (安神), and restoring nighttime recovery physiology. Insomnia, skin aging, and fatigue-related skin changes can thus be understood as manifestations of a shared pathological axis involving melatonin dysregulation and Yin-Blood deficiency. Integrating plant-derived melatonin intake with traditional Korean medical interventions such as Yin-nourishing herbal prescriptions and acupuncture may offer synergistic benefits for sleep improvement and skin anti-aging.
87 황기추출물의 피부 재생 및 면역조절 효능에 대한 고찰 ― 기허(氣虛) 중심 피부 항상성 이론 확장 이성환 2025-07-01 ~ 학회지
Objects: The skin is a dynamic organ responsible for maintaining homeostasis through coordinated regulation of regeneration, immune defense, and barrier function. Impairment of these processes is closely associated with chronic inflammation, delayed wound healing, and accelerated skin aging. In traditional Korean medicine, such systemic dysregulation is conceptualized as Qi-deficiency (氣虛). Astragalus membranaceus (Huangqi) has long been used as a representative Qi-tonifying herb. This study aimed to review the skin regenerative and immunomodulatory effects of Astragalus membranaceus and to reinterpret these effects within a Qi-deficiency–centered framework of skin homeostasis through an integrative East–West medical perspective.
Methods: This study was conducted as a narrative literature review. Relevant domestic and international publications addressing Qi-deficiency pathology, skin regeneration, immune regulation, homeostasis, and the pharmacological effects of Astragalus membranaceus were systematically reviewed and qualitatively analyzed. Traditional Korean medical theories were examined in parallel with contemporary biomedical findings to identify conceptual correspondences and shared regulatory mechanisms related to skin regeneration and immune balance.
Conclusions: Qi-deficiency was identified as a fundamental pathological condition characterized by impaired energy regulation, immune imbalance, and disrupted skin homeostasis. Astragalus membranaceus exerts skin regenerative effects indirectly by correcting Qi-deficiency through enhancement of energy metabolism, immune modulation, microcirculation, and barrier stabilization. From an integrative perspective, Astragalus does not merely stimulate local tissue repair but facilitates skin regeneration by restoring systemic homeostatic regulation. This review proposes an expanded theoretical model in which Qi-deficiency correction serves as a central axis linking immune regulation and skin regeneration, providing a conceptual foundation for integrative dermatological and regenerative medicine research.
86 NMN–NAD⁺ Axis와 한의학 정(精) 생리의 통합적 모델 제시 : 세포 노화와 피부 미용을 중심으로 이성환 2025-01-01 ~ 학회지
Objects: Age-related decline in nicotinamide adenine dinucleotide (NAD⁺) is recognized as a key molecular mechanism underlying mitochondrial dysfunction, impaired DNA repair, chronic inflammation, and epigenetic instability. In traditional Korean medicine (TKM), aging has long been understood as a progressive depletion of Jing (精), Qi (氣), accompanied by dysregulation of Shen (神) and meridian flow (Jingluo, 經絡). This study aims to explore the theoretical convergence between the NMN–NAD⁺ axis and classical TKM pathology, and to propose an integrative model of aging and skin rejuvenation linking molecular biology with Korean medicine.
Methods: A narrative integrative review was performed using highly cited literature on NAD⁺ metabolism, NMN supplementation, mitochondrial function, Sirtuin signaling, DNA repair (PARP), inflammation, and oxidative stress. These biological mechanisms were systematically mapped onto TKM pathological concepts, including Jing deficiency, Qi deficiency, Shen dysregulation, and meridian stagnation. Furthermore, herbal medicine, formula-based therapy, and acupuncture interventions were reinterpreted according to their correspondence with NAD⁺-mediated cellular recovery pathways.
Conclusions: The NMN–NAD⁺ axis is proposed as a molecular analogue of the traditional Jing–Qi–Shen–Jingluo framework, offering a unified explanation for aging and skin degeneration across Eastern and Western medical paradigms. This integrative perspective provides a novel theoretical foundation for anti-aging and skin rejuvenation strategies and supports the development of evidence-based integrative medical approaches.
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