| 11 |
고지방식이로 유도된 비만 동물 모델에서 평위산, 후박, 창출의 항비만 효능 비교 연구 |
서민규, 박예진, 강윤미, 김희영, 한인식, 안효진 |
2021.08.04 ~ |
학회지 |
| Objectives Obesity is considered a global epidemic that greatly affects general population health, and there has been a growing interest in the development of anti-obesity drugs worldwide. There are many hepatic and gastrointestinal diseases for which obesity is the direct cause or is a serious risk factor. Pyungwi-san (PWS) is a traditional oriental herbal prescription used to treat gastrointestinal disorders. Atractylodes chinensis (DC.) Koidzumi (AC) and Magnolia officinalis Rehder & E.H. Wilson (MO) are main components of PWS. In this present study, anti-obesity effects of PWS, MO, and AC were investigated in high-fat diet (HFD)-induced obese mouse model. Methods Eight-week-old male C57BL/6N were fed 45% HFD for 8 weeks. For comparison of PWS, MO, and AC for obesity, the body weight, food intake, and white adipose tissue (WAT) weights were checked. In addition, hematoxylin and eosin staining for histological examination were performed to observe lipid droplets in epididymal WAT and liver tissue. Results Among them, AC had powerful effects on reduction of body weight, epididymal and visceral WAT weight, and regulation of the levels of serum total cholesterol and triglyceride. In addition, PWS, MO, and AC treatment ameliorated the HFD-induced histological changes in the epididymal WAT and liver tissue. Conclusions These findings demonstrate that AC has anti-obesity effects and would be evaluated as a potential treatment for obesity. |
| Objectives Fatigue sub-health is one of the representative types of sub-health, and refers to a sub-health state with fatigue as the main symptom. The purpose of this study was to review the diagnostic criteria for the fatigue sub-health in Chine, and to suggest a direction for developing diagnostic criteria suitable for Korea. Methods Chinese databases, CNKI, Wanfang and CQVIP, were used to search literatures related to fatigue sub-health, and articles describing the diagnostic criteria for fatigue sub-health were summarized. Results As the diagnostic criteria for fatigue sub-health was established, research to prepare full-scale diagnostic criteria started, and various diagnostic criteria for fatigue sub-health have been proposed by many researchers. Therefore, the world federation of Chinese medicine societies reviewed the diagnostic criteria for fatigue sub-health proposed, established new diagnostic criteria in 2020, and approved it as a society standard. Conclusions It is unreasonable to apply the Chinese diagnostic criteria for fatigue sub-health to Korea with different cultural and social backgrounds. Therefore, it is necessary to develop diagnostic criteria for fatigue sub-health that are suitable for Korea as soon as possible. |
| The main pattern of the Mibyeong (subhealth syndrome) is associated with the environmental or constitutional characteristics of the individual and is not clearly associated with the disease, there are many cases that begin with fatigue, sleep disorders, pain, etc. In Sasang constitutional medicine, mental, physical, and social control is managed through diet, exercise, regimen, etc. through the constitutional regimen, while being holistic. When these constitutional management methods are properly applied in life, the body and mind can be adjusted to a healthy and stable state, and furthermore, a healthy social person will be able to lead a healthy and happy life. |
| Objectives The purpose of this study is to provide information and basic data related to the establishment of research directions to researchers planning future gastrointestinal disease-related clinical studies by review gastrointestinal diseases clinical studies using Chinese medicinal food therapy. Methods This study reviewed the clinical research articles on gastrointestinal disease form the China National Knowledge Infrastructure (CNKI) system using the keywords ‘Yaoshan’ and ‘Zhongyishiliao’ from 2016 to 2018. And analysed for research participants, research period, research subject, type of treatment plan, Yaksun intervention type, Yaksun formulation, and Yaksun prescription composition. Results The number of participants in the clinical study was 94.3 on average, with males participating more than females, with an average age of 43.68 years old. The most frequent study period was between 4 and 6 weeks, and the topic of the study was stomach ulcers the most. There were 10 studies by pattern identification, of which cold deficiency pattern was 4. Most of the studies chose a combination with the Chinese medicine or Western medicine. Porridge is the most used formulation and mainly ingredients and grain with the efficacy of fortify the spleen and replenish Qi and regulate Qi and resolve dampness. Conclusions Gastrointestinal disease is a disease that is closely related to diet. Therefore, it is hoped that this study will motivate researchers interested in clinical research using Korean medicinal food therapy. |
