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번호	연구제목	연구자	연구기간	발표실적
번호	내용
122	경락의 해부학적 실체	송석모	2023-09-01 ~	학술대회
122	경맥에 대한 현대연구와 △마왕퇴 경맥서 비음맥(맥박의 연속체) △상지의 수태음폐경 △머리의 표층경맥(수족삼양경) △기경팔맥과 동맥 등 고전의 동맥을 비교하면서 “이는 고대 경맥이 맥박의 촉각적 탐색에 의해 발견됐다는 가설을 증명하는 것으로, 실제 인체의 손바닥, 하완, 상완, 겨드랑이, 옆구리에서 맥박을 촉각적으로 탐색이 가능하며, 신체 확인된 맥박의 위치들과 고전에서 기술하는 경맥의 위치와 노선이 일치함을 확인했다”고 설명함. 옛날 사람들이 지칭하는 경락과 현대 해부학에서의 경락은 지시체(Reference)가 유사하지만 내포된 의미는 다르게 해석할 수 있으며, 경맥은 주요동맥(Main arteries)으로, ‘영추·경맥’의 12경맥은 주요 동맥의 도식화된 간략한 스케치이고, 기경(奇經)은 12경맥에 포함되지 않는 부위의 주요동맥으로 분석함.
121	MPTP로 유도된 파킨슨병 생쥐 모델에 대한 시호계지탕, 시호소간탕, 시호청간탕의 신경세포 보호 효과 비교 연구	서지은, 이한울, 배창환, 윤동학, 김희영, 김승태	2023-07-01 ~	학회지
121	Objectives : Parkinson’s disease (PD) is the second most common neurodegenerative disorder worldwide and is characterized by the loss of the dopaminergic neurons in the substantia nigra (SN). In a previous in vitro study, we demonstrated that Sihogyeji-tang (SG), Sihosogan-tang (SS), and Sihocheonggan-tang (SC) have the potential to be candidate medicines for PD. This study aimed to compare the neuroprotective effect of SG, SS, and SC using 1-methyl-4-phenyl-1,2,3,6-tetrahydrophridine (MPTP)-induced PD mouse model. Methods : Eight-week-old male C57BL/6 mice were intraperitoneally administered with 30 mg/kg of MPTP for 5 days and orally administered SG, SS and SC for 12 days from the first MPTP injection. Motor function was assessed using the pole test and the rotarod test. Dopaminergic neuronal survival in the SN and striatum was evaluated through tyrosine-hydroxylase immunohistochemistry. Results : MPTP administration resulted in behavioral impairment and dopaminergic neuronal death in the SN and striatum. In the pole test, treatment with SG, SS, and SC alleviated the MPTP-induced motor dysfunction on day 5 and 12. In the rotarod test, SS and SG alleviated the MPTP-induced motor dysfunction on day 5, while only SS showed improvement on day 12. SS and SG significantly protected dopaminergic neurons in the SN from MPTP toxicity, and all three compounds (SG, SS, and SC) showed significant protection in the striatum. Notably, SS demonstrated superior efficacy in suppressing MPTP-induced motor dysfunction and dopaminergic neuronal death compared to SG and SC. Conclusions : These findings suggest that SS is the most effective formula among SG, SS, and SC for PD, indicating its potential role in the treatment of PD.
120	건강한 성인의 소화 상태 및 소화 불편에 따른 복진용 압통장치를 활용한 정량적 연구	김대혁, 김영은, 이상훈, 박정환	2023-07-01 ~	학회지
120	Objectives : The aim of this study was to assess the quantitative characteristics of pressure pain threshold (PPT) and pressure depth (PD) at the abdominal conception vessel (CV) acupoints according to subjective digestive status and digestive discomfort levels, accomplished by comparing a large group of healthy men and women, using the modified digital algometer. Methods : A total of 1,504 healthy adults aged 19 years or older participated in this study. A questionnaire was administered to evaluate participants' digestive status and discomfort. PPT (kgf/cm2/s) and PD (mm) measurements were obtained at CV14, CV12, and CV4 acupoints using a modified digital algometer. General characteristics were analyzed using the chi-square test, and differences in PPT and PD were assessed using two-sample t-tests and ANCOVA. Results : Significant difference in PPT was found based on digestive status at CV14 and CV12 for both sexes, and in PD at CV14 for women. Women exhibited significant difference in PPT based on digestive discomfort at CV14, CV12, and CV4, while men showed significant difference at CV14 and CV12. Significant difference in PD was observed at CV14 and CV4 among women. Even after adjusting for age and body mass index, significant difference persisted in PPT based on digestive discomfort at CV14 and CV12 for both sexes. PD exhibited significant differences at CV14, CV12, and CV4 among women. Conclusions : Using the modified digital algometer, this study showed the significant difference of pressure pain threshold at the CV14 and CV12 acupoints for subjective digestive discomfort levels in healthy men and women.
119	고지방식이 및 일반식이 백서에 대한 중완ㆍ천추ㆍ족삼리 침자의 유효성 검증	김경수, 김명훈, 설재욱, 김은주, 손홍석, 나창수	2023-07-01 ~	학회지
119	Objectives : It was conducted to experimentally analyze the effects of acupuncture treatment at CV12, ST25, and ST36 on weight, FBCS, fat metabolism, microbiome, and metabolome changes in the general diet rat and the high-fat diet rat. Methods : It was classified into four groups: general diet & non-treatment group (ND), general diet & acupuncture treatment group (ND+AT), high-fat diet & non-treatment group (HFD), and high-fat diet & acupuncture treatment group (HFD-AT). After acupuncture treatment was performed on CV12, ST25, and ST36, changes in body weight, FBCS, fat metabolism, microbiome, and metabolome were analyzed. Results : Compared to the ND group, acupuncture treatment performed on CV12, ST25, and ST36 in the ND+AT group had no significant effect. Compared to the HFD group, CV12, ST25, and ST36 acupuncture in the HFD+AT group reduced weight, fat weight, inflammatory cytokine IL-6 expression, and lipid droplet accumulation in liver tissue. Acupuncture can promote fat metabolism and relieve inflammatory conditions. Differences in diversity between ND and HFD groups were clear in changes in microbiome, fecal metabolites, and serum metabolites. As a result of some microbiome and metabolites involved in fat decomposition, intestinal lipid absorption, and blood lipid concentration control, such as Intestinimonas, Ruminococcus 1, pyroglutamic acid, tryptophan, and inositol, it was observed that the acupuncture treatment effect was evident in the disease-induced imbalance. Conclusions : Acupuncture treatment performed on CV12, ST25, ST36 clearly observed various regulatory actions on obesity induced by high-fat diet, confirming that the action of acupuncture treatment mainly plays a role in controlling an unbalanced state.