회원학회

회원학회

번호 연구제목 연구자 연구기간 발표실적
내용
256 항우울제와 한약제제의 병용투여지침 개발-에스시탈로프람과 보험 4종 한약제제를 중심으로· 이도은, 고경진, 김영우, 김춘옥, 강형원 2024-07-01 ~ 학회지
Objectives: To develop guidelines for concomitant use of four herbal medicines (Gamisoyosan, Banhasasimtang, Ojeoksan, and Bojungikgitang) with escitalopram.
Methods: A guideline development team was assembled and relevant prior research was systematically reviewed to gather evidence. The potential for drug interactions was evaluated by analyzing changes in pharmacokinetic parameters. Safety was assessed through the analysis of adverse drug reactions associated with combined use. Recommendations and concomitant administration guidelines were formulated through a consensus process.
Results: No significant drug interactions were identified between the four herbal medicines and escitalopram, indicating no need for dosage adjustment of escitalopram. However, it is recommended to monitor potential adverse reactions during concurrent use.
Conclusions: This study provides recommendations for combined use of four herbal medicines covered by domestic insurance combined with escitalopram. Further research on interactions between antidepressants and herbal medicine is necessary to refine and enhance concomitant administration guidelines.
255 불안, 우울, 분노 및 불면 증상에 대한 한의학파 처방 추천 임상 데이터 구축을 위한 기초 연구 강동훈, 김주연, 이지윤, 김제현, 예상준, 장 호, 이상훈, 정인철 2024-07-01 ~ 학회지
Objectives: To build basic clinical data for developing an artificial intelligence algorithm for Korean herbal prescriptions for anxiety, depression, anger, and insomnia. Methods: Subjects were recruited among those who reported mild or more severe symptoms of anxiety, depression, anger, and insomnia (Anxiety: State-Trait Anxiety Inventory≥40, Depression: Beck Depression Inventory≥14, Anger: State-Trait Anxiety Inventory≥16, Insomnia: Insomnia Severity Index≥8). Clinical observation items including basic medical information and symptoms were col
lected from them. These data were then analyzed by experts in Hyungsang medicine, Sasang constitutional medicine, and Sanghan-Geumgwe medicine.
Results and Conclusions: Experts of the three societies presented key clinical data and recommended prescriptions. Results of this study can be used as basic data for developing an artificial intelligence algorithm for Korean herbal prescriptions in the future.
254 소아ㆍ청소년의 우울장애 환자에 대한 한의치료의 효과 및 불안, 분노 심리척도 상관성 분석: 후향적 관찰 연구 조한별, 김연주, 유종호 2024-07-01 ~ 학회지
Objectives: To examine effect of Korean medical treatment on child and adolescent patients with depressive disorder and correlations among changes in anxiety and anger psychological scales before and after treatment.
Methods: Medical records of 28 adolescent and 9 child patients diagnosed with depressive disorder based on Diagnostic and Statistical Manual of Mental Disorders-V (DSM-V) who received Korean medical treatment (herbal-medication, acupuncture, Korean psychotherapy, and so on) for at least 8 weeks were retrospectively reviewed. Psychological scales including Beck Depression Inventory-II (BDI-II), State-Trait Anxiety Inventory (STAI), Beck Anxiety Inventory (BAI), State-Trait Anger Expression Inventory (STAXI), Children’s Depression Inventory (CDI), State Anxiety Inventory for Children (SAIC), Trait Anxiety Inventory for Children (TAIC), and Children’s Inventory of Anger (ChIA) were measured
every four weeks and analyzed.
Results: After eight weeks of treatment, STAI-X-1 (State Anxiety), STAI-X-2 (Trait Anxiety), BDI-2, BAI, STAXI-S (State Anger), AXI-K-I (Anger Expression-In) and AXI-K-O (Anger Expression-Out) showed statistically significant decreases in adolescent patients. In child patients, ChIA was significantly improved after eight weeks. For psychological scale pairs in adolescent patients, BDI-2 and STAI-X-1ㆍSTAI-X-2ㆍBAIㆍSTAXI-SㆍAXI-K-I, STAIX-T and STAXI-SㆍAXI-K-I showed significant positive correlations whereas AXI-K-O and AXI-K-C showed a negative correlation. In child paitents, there was a significant positive correlation for all psychological scales except for the relationship between SAIC and ChIA. In adolescent patients, low pretreatment BDI-2 predicted BAI, STAXI-S, and AXI-K-I score reduction after 8 weeks. Lower BAI scores significantly decreased STAI-X-2 and BDI-2 scores after 8 weeks but increased AXI-K-C. In child paitents, low pretreatment ChIA scores predicted a decrease in CDI score after treatment.
Conclusions: Korean medical treatments including herbal medicine, acupuncture, and Korean psychotherapy were effective in improving depressive disorder and accompanying symptoms such as anxiety and anger of child and adolescent patients.
253 파킨슨병으로 인한 우울증의 한의 임상연구 고찰 김정원, 남태광, 김안나, 오용택 2024-07-01 ~ 학회지
Objectives: Parkinson’s disease is a degenerative neurological disorder caused by dopamine neuron damage, leading to various motor and non-motor symptoms, including depression. While several clinical studies on Traditional Korean Medicine (TKM) have addressed this issue, no comprehensive review has been conducted. This study aimed to summarize and analyze TKM treatments for depression associated with Parkinson’s disease.
Methods: This study reviewed research focused on treatment of Parkinson’s-related depression, particularly examining traditional therapies such as acupuncture and herbal medicine. Data on treatment methods were analyzed to compare approaches of control and experimental groups. Specific use of acupuncture points and other TKM treatments was analyzed.
Results: Out of 57 studies, 17 involving 649 participants were selected. Various treatment methods were evaluated, primarily using the Unified Parkinson’s Disease Rating Scale (UPDRS). Studies predominantly focused on acupuncture targeting specific points (such as LI 4, GB 20, and ST 36) and the use of various herbal medicine combinations.
Conclusions: Of the 17 studies, 13 focused on effects of acupuncture, suggesting that acupuncture might play a significant role in alleviating depression associated with Parkinson’s disease. Specifically, the use of acupuncture points such as LI 4, GB 20, and ST 36 showed potential therapeutic effects. Additionally, 13 studies demonstrated that TKM could significantly alleviate depression, indicating the
potential for an integrative approach combining Eastern and Western therapies. Herbal medicine and Qigong dance therapy also showed promising effects in improving depression.
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