회원학회

회원학회

번호 연구제목 연구자 연구기간 발표실적
내용
498 Journal of Pharmacouncture (Vol 27, No.2) Jihyun Cha 2024-06-30 ~ 학회지
Preclinical Evidence and Underlying Mechanisms of Polygonum multiflorum and Its Chemical Constituents Against Cognitive Impairments and Alzheimer’s Disease

Objectives: Cognitive impairments, ranging from mild to severe, adversely affect daily
functioning, quality of life, and work capacity. Despite significant efforts in the past decade,
more than 200 promising drug candidates have failed in clinical trials. Herbal remedies
are gaining interest as potential treatments for dementia due to their long history
and safety, making them valuable for drug development. This review aimed to examine the
mechanisms behind the effect of Polygonum multiflorum on cognitive function.
Methods: This study focused primarily on the effects of Polygonum multiflorum and its
chemical constituents on cognitive behavioral outcomes including the Morris water maze,
the passive avoidance test, and the Y maze, as well as pathogenic targets of cognitive impairment
and Alzheimer’s disease (AD) like amyloid deposition, amyloid precursor protein,
tau hyperphosphorylation, and cognitive decline. Additionally, a thorough evaluation of the
mechanisms behind Polygonum multiflorum’s impact on cognitive function was conducted.
We reviewed the most recent data from preclinical research done on experimental models,
particularly looking at Polygonum multiflorum’s effects on cognitive decline and AD.
Results: According to recent research, Poligonum multiflorum and its bioactive components,
stilbene, and emodin, influence cognitive behavioral results and regulate the pathological
target of cognitive impairment and AD. Their mechanisms of action include reducing
oxidative and mitochondrial damage, regulating neuroinflammation, halting apoptosis,
and promoting increased neurogenesis and synaptogenesis.
Conclusion: This review serves as a comprehensive compilation of current experiments on
AD and other cognitive impairment models related to the therapeutic effects of Polygonum
multiflorum. We believe that these findings can serve as a basis for future clinical trials
and have potential applications in the treatment of human neurological disorders.
497 Journal of Pharmacouncture (Vol 27, No.2) Reza Tahvilian 2024-06-30 ~ 학회지
The Effect of the Combination of Ginseng, Tribulus Terrestris, and L-arginine on the Sexual Performance of Men with Erectile Dysfunction: a randomized, doubleblind, parallel, and placebo-controlled clinical trial

Objectives: Nitric oxide is the most important mediator of penile erection after the onset
of sexual excitement. It activates cyclic guanosine monophosphate (cGMP), increasing
penile blood flow. Most pharmaceutical medications prevent enzyme phosphodiesterase
type 5 (PDE-5) from breaking down cGMP, thus keeping its level high. However, due to the
adverse effects of pharmacological therapies, herbal drugs that improve sexual function
have gained attention recently. This study aimed to investigate the combined effects of
ginseng, Tribulus terrestris , and L-arginine amino acid on the sexual performance of individuals
with erectile dysfunction (ED) using the 5-item version of the International Index of
Erectile Function (IIEF-5) questionnaire.
Methods: Over three months, 98 men with erectile dysfunction were randomly assigned
to receive either 500 mg of herbal supplements or placebo pills. Each herbal tablet contained
100 mg of protodioscin, 35 mg of ginsenosides, and 250 mg of L-arginine.
Results: The results showed that the changes in the average scores of ILEF-5 within each
group before and after the intervention indicated that all parameters related to the improvement
of sexual function in patients with erectile dysfunction improved in the herbal
treatment group (p < 0.001). The herbal group significantly improved IIEF-5 scores in nondiabetics
(p < 0.05). However, there was no significant difference in the changes of IIEF-5
scores between the two intervention and control groups in diabetic patients.
Conclusion: In conclusion, ginseng, Tribulus terrestris , and L-arginine have properties that
increase energy and strengthen sexual function, making them suitable for patients with
sexual disorders.
496 Journal of Pharmacouncture (Vol 27, No.2) Mithil Vora 2024-06-30 ~ 학회지
Computational Evaluation on the Interactions of an Opaque-Phase ABC Transporter Associated with Fluconazole Resistance in Candida albicans , by the Psidium guajava Bio-Active Compounds

Objectives: Candida albicans is an opportunistic pathogen that occurs as harmless commensals
in the intestine, urogenital tract, and skin. It has been influenced by a variety of
host conditions and has now evolved as a resistant strain. The aim of this study was thus
detect the fluconazole resistant C. albicans from the root caries specimens and to computationally
evaluate the interactions of an opaque-phase ABC transporter protein with the
Psidium guajava bio-active compounds.
Methods: 20 carious scrapings were collected from patients with root caries and processed
for the isolation of C. albicans and was screened for fluconazole resistance. Genomic
DNA was extracted and molecular characterization of Cdrp1 and Cdrp2 was done by
PCR amplification. P. guajava methanolic extract was checked for the antifungal efficacy
against the resistant strain of C. albicans . Further in-silico docking involves retrieval of ABC
transporter protein and ligand optimization, molinspiration assessment on drug likeness,
docking simulations and visualizations.
Results: 65% of the samples showed the presence of C.albicans and 2 strains were fluconazole
resistant. Crude methanolic extract of P. guajava was found to be promising
against the fluconazole resistant strains of C. albicans . In-silico docking analysis showed
that Myricetin was a promising candidate with a high docking score and other drug ligand
interaction scores.
Conclusion: The current study emphasizes that bioactive compounds from Psidium guajava
to be a promising candidate for treating candidiasis in fluconazole resistant strains of
C. albicans However, further in-vivo studies have to be implemented for the experimental
validation of the same in improving the oral health and hygiene.
495 Journal of Pharmacouncture (Vol 27, No.2) Martohap Parotua Lumbanraja 2024-06-30 ~ 학회지
Pandanus amaryllifoius Roxb. Leaves Ethanol Extract Ameliorates Lipid and Proinflammatory Cytokines Profiles in a Rat Model of Dyslipidemia

Objectives: Dyslipidemia has currently become a major health challenge that still opens
for safer and more effective modes of treatment. The plant Pandanus amaryllifolius Roxb.
(pandan) has been indicated to contain active ingredients that interfere with the pathological
pathway of dyslipidemia. The aim of the study was to test the effects of pandan leaves
ethanol extract on lipid and proinflammatory profiles in a rat dyslipidemic model.
Methods: Dyslipidemia was induced by administration of high-fat feed for 8 weeks. Treatments
(vehicle, the reference drug simvastatin at 1.8 mg/kg, and extract at 200, 300 or
600 mg/kg) were given for 4 weeks following the completion of induction.
Results: Significant post-treatment decreases in total cholesterol, low density lipoprotein
(LDL), and triglyceride levels in groups receiving all doses of extract and simvastatin were
observed. Similar results were also found in regards to proinflammatory cytokines levels.
Pandan extracts significantly lowered the concentrations of IL-6, TNF-α, and NFκB p65.
Characterization of metabolite contents of the extract confirmed the presence of the previously
suggested active alkaloids pandamarilactonine-A and B.
Conclusion: Taken together, results of the present study implied the ameliorating effects
of pandan leaves ethanol extract in dyslipidemic condition which is potential for opening
an avenue in combating this essential component of metabolic disorder.
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